SUPPLEMENT

Introduction: Asthma in the New Millennium

Richard J. Martin and Monica Kraft
Chest 123: 339S. [Full Text] [PDF]  

Transgenic Modeling of Interleukin-13 in the Lung

Jack A. Elias, Tao Zheng, Chun Geun Lee, Robert J. Homer, Qingsheng Chen, Bing Ma, Michael Blackburn, and Zhou Zhu
Chest 123: 339S-345S. [Abstract] [Full Text] [PDF]  

Overlap Between Death Receptor and Non-Receptor-Mediated Mechanisms During Apoptosis in Human Eosinophils

Sultan Niazi, Noreen M. Robertson, Ashish Agrawal, Annette T. Hastie, Stephen P. Peters, and James Zangrilli
Chest 123: 345S. [Full Text] [PDF]  

Isolation and Characterization of Hemopoietic Cells From Lungs of Allergic Mice

Maria Ignez C. Gaspar Elsas, Elisabeth S. Maximiano, Danielle Joseph, Adriana Bonomo, Bernardo Boris Vargaftig, and Pedro Xavier Elsas
Chest 123: 345S-348S. [Abstract] [Full Text] [PDF]  

Contribution of the Distal Lung to the Pathologic and Physiologic Changes in Asthma: Potential Therapeutic Target Roger S. Mitchell Lecture

Meri K. Tulic and Qutayba Hamid
Chest 123: 348S-355S. [Abstract] [Full Text] [PDF]  

Hydrolysis of Surfactant Phospholipids Catalyzed by Phospholipase A₂ and Eosinophil Lysophospholipases Causes Surfactant Dysfunction: A Mechanism for Small Airway Closure in Asthma

Steven J. Ackerman, Mark A. Kwatia, Christine B. Doyle, and Goran Enhorning
Chest 123: 355S. [Full Text] [PDF]  

Interleukin-4 and Interleukin-13 Augment the Proliferative Effect of Dexamethasone on Distal Lung Fibroblasts

Christina C. Lewis, E. Rand Sutherland, T.A. Moss, Terri L. Metze, M.D. Rex, and Monica Kraft
Chest 123: 356S. [Full Text] [PDF]  

The Functional Consequences of Structural Changes in the Airways: Implications for Airway Hyperresponsiveness in Asthma

Lu Wang, Brent E. McParland, and Peter D. Paré
Chest 123: 356S-362S. [Full Text] [PDF]  

Role of Fibrin in Determining Airway Closure

Scott Wagers, Ryan Norton, Jason Bates, and Charles G. Irvin
Chest 123: 362S-363S. [Full Text] [PDF]  

Peripheral Lung Responsiveness Assessed by Forced Oscillations Through the Wedged Bronchoscope

David A. Kaminsky, C.G. Irvin, H.T. Moriya, M. Lynn, S. Lang, and J.H.T. Bates
Chest 123: 363S. [Full Text] [PDF]  

Mapping Susceptibility Genes for Allergic Diseases

Timothy D. Howard, Deborah A. Meyers, and Eugene R. Bleecker
Chest 123: 363S-368S. [Abstract] [Full Text] [PDF]  

Effect of Dexamethasone on ß₂-Adrenergic Desensitization in Airway Smooth Muscle: Role of the ARG19 Polymorphism

Paul E. Moore, Mark M. Calder, Eric S. Silverman, Reynold A. Panettieri, Jr., and Stephanie A. Shore
Chest 123: 368S-369S. [Full Text] [PDF]  

The Genetics of Innate Immunity in the Lung

Donald N. Cook, Shuibang Wang, Gabriel P. Howles, Marcy Speer, Gary Churchhill, John Quackenbush, and David A. Schwartz
Chest 123: 369S. [Full Text] [PDF]  

Macrophage Inflammatory Protein-2 Levels Are Associated With Changes in Serum Leptin Concentrations Following Ozone-Induced Airway Inflammation

Richard A. Johnston, Igor N. Schwartzman, and Stephanie A. Shore
Chest 123: 369S-370S. [Full Text] [PDF]  

Increased Expression of Interleukin-9 Messenger RNA After Segmental Allergen Challenge in Allergic Asthmatics

Veit J. Erpenbeck, Jens M. Hohlfeld, Marc Discher, Harald Krentel, Andreas Hagenberg, Armin Braun, and Norbert Krug
Chest 123: 370S. [Full Text] [PDF]  

Increased Messenger RNA Expression of c-maf and GATA-3 After Segmental Allergen Challenge in Allergic Asthmatics

Veit J. Erpenbeck, Jens M. Hohlfeld, Marc Discher, Harald Krentel, Andreas Hagenberg, Armin Braun, and Norbert Krug
Chest 123: 370S-371S. [Full Text] [PDF]  

UCB 62045: Pharmacology of a Novel, Dual-Function Anti-inflammatory Agent With Histamine Type 1 Receptor Antagonist and 5-Lipoxygenase Inhibitor Activity

William M. Selig, Lynn Bayless, Lyn Libertine, Joseph B. Eckman, Donna M. Wypij, Bruce F. Wels, Maria Eckert, Michelle A. Young, Jean M. Nicolas, Ralph T. Scannell, and James L. Ellis
Chest 123: 371S. [Full Text] [PDF]  

The Relationship of Induced-Sputum Inflammatory Cells to BAL and Biopsy

Philip E. Silkoff, John B. Trudeau, Robyn Gibbs, and Sally Wenzel
Chest 123: 371S-372S. [Full Text] [PDF]  

Eosinophil Cationic Protein Concentration in Saliva Does Not Correlate With Eosinophil Cationic Protein Concentration in Sputum

David L. Bowton, Michael C. Seeds, and David A. Bass
Chest 123: 372S. [Full Text] [PDF]  

Interferon- Reduces Interleukin-4– and Interleukin-13–Augmented Transforming Growth Factor-ß₂ Production in Human Bronchial Epithelial Cells by Targeting Smads

Fu-Qiang Wen, Xiangde D. Liu, Yusuke Terasaki, Qiuhong H. Fang, Tetsu Kobayashi, Shinji Abe, and Stephen I. Rennard
Chest 123: 372S-373S. [Full Text] [PDF]  

Interleukin-13 Alters Mucociliary Differentiation of Human Nasal Epithelial Cells

Marie Skowron, Eric Perret, Francelyne Marano, Daniel Caput, and Frédéric Tournier
Chest 123: 373S-374S. [Full Text] [PDF]  

Identification of Genes and Proteins Regulated by Interleukin-5 in Human Eosinophils Using Microarrays and Two-Dimensional Electrophoresis/Mass Spectrometry

Sara Håkansson, Karin Behrens, György Marko-Varga, Henrik Lindberg, Stefan Pierrou, and Witte Koopmann
Chest 123: 374S. [Full Text] [PDF]  

Lack of Association Between the Tumor Necrosis Factor- Regulatory Region Genetic Polymorphisms Associated With Elevated Tumor Necrosis Factor- Levels and Children With Asthma

Lama El Bahlawan, Michael Christensen, Said Binaei, Cathy Murphy, Qing Zhang, and Micheal Quasney
Chest 123: 374S-375S. [Full Text] [PDF]  

ß₂-Adrenergic Receptor Polymorphisms in Children With Status Asthmaticus

Saeed Binaei, Michael Christensen, Cathy Murphy, Qing Zhang, and Michael Quasney
Chest 123: 375S. [Full Text] [PDF]  

Interleukin-13 Induces Surfactant Function Abnormality in the Murine Lung

Zhou Zhu, Goran Enhorning, Tao Zheng, Qingsheng Chen, Ning Yuan Chen, Robert Homer, and Jack A. Elias
Chest 123: 375S-376S. [Full Text] [PDF]  

Human Eosinophil Group IID Secretory Phospholipase A₂ Causes Surfactant Dysfunction

Michael C. Seeds, David L. Bowton, R. Duncan Hite, Julianna I. Gyves, and David A. Bass
Chest 123: 376S-377S. [Full Text] [PDF]  

Modulation of Vasodilator-Stimulated Phosphoprotein In Vivo in Human Epithelial Cells by Segmental Allergen Challenge and ß₂-Agonist Therapy

Annette T. Hastie, Vikas Batra, Sandhya Khurana, Kathy A. Carpenter, Rosemary Cirelli, James G. Zangrilli, and Stephen P. Peters
Chest 123: 377S. [Full Text] [PDF]  

Developing the Epithelial, Viral, and Allergic Paradigm for Asthma: Giles F. Filley Lecture

Michael J. Holtzman, Eugene Agapov, Edy Kim, Joo-in Kim, and Jeffrey D. Morton
Chest 123: 377S-384S. [Full Text] [PDF]  

Proliferation of the Airway Epithelium in Asthma: Are Inflammatory Cells Required?

Brian W. Booth, Dawn C. Newcomb, Shaun A. McKane, Anne L. Crews, Kenneth B. Adler, James C. Bonner, and Linda D. Martin
Chest 123: 384S-385S. [Full Text] [PDF]  

Histamine Decreases E-Cadherin-Based Adhesion To Increase Permeability of Human Airway Epithelium

Joseph Zabner, Michael C. Winter, Sandra Shasby, Dana Ries, and D. Michael Shasby
Chest 123: 385S. [Full Text] [PDF]  

Is Asthma an Infectious Disease?: Thomas A. Neff Lecture

Robert F. Lemanske, Jr.
Chest 123: 385S-390S. [Abstract] [Full Text] [PDF]  

Hygiene Hypothesis of Asthma: A Murine Asthma Model With Mycoplasma pneumoniae Infection

Hong Wei Chu, Joyce M. Honour, Catherine A. Rawlinson, Ronald J. Harbeck, and Richard J. Martin
Chest 123: 390S. [Full Text] [PDF]  

Mechanisms That Potentially Underlie Virus-Induced Exaggerated Inflammatory Responses By Airway Epithelial Cells

René Lutter, Matthijs van Wissen, Thierry Roger, Paul Bresser, Koen van der Sluijs, Monique Nijhuis, and Henk M. Jansen
Chest 123: 391S-392S. [Full Text] [PDF]  

Actin Dynamics: A Potential Integrator of Smooth Muscle (Dys-)Function and Contractile Apparatus Gene Expression In Asthma

Julian Solway, Shashi Bellam, Maria Dowell, Blanca Camoretti-Mercado, Nickolai Dulin, Darren Fernandes, Andrew Halayko, Pawel Kocieniewski, Paul Kogut, Oren Lakser, Hong Wei Liu, Joel McCauley, John McConville, and Richard Mitchell
Chest 123: 392S-398S. [Full Text] [PDF]  

Concentration of Cytokines and Growth Factors in BAL Fluid After Allergen Challenge in Asthmatics and Their Effect on -Smooth Muscle Actin and Collagen III Synthesis by Human Lung Fibroblasts

Vikas Batra, Sandhya Khurana, Ali I. Musani, Annette T. Hastie, Katherine A. Carpenter, James G. Zangrilli, and Stephen P. Peters
Chest 123: 398S-399S. [Full Text] [PDF]  

Nocturnal Asthma

William J. Calhoun
Chest 123: 399S-405S. [Abstract] [Full Text] [PDF]  

Hypothalamic-Pituitary-Adrenal Axis Dysfunction During Sleep in Nocturnal Asthma

E. Rand Sutherland, Monica Kraft, M.D. Rex, Misoo C. Ellison, and Richard J. Martin
Chest 123: 405S. [Full Text] [PDF]  

Severe/Fatal Asthma

Sally Wenzel
Chest 123: 405S-410S. [Abstract] [Full Text] [PDF]  

Allergen-Specific Early Neutrophil Infiltration After Allergen Challenge in a Murine Model

Christian Taube, Azzeddine Dakhama, Katsuyuki Takeda, Jerry A. Nick, and Erwin W. Gelfand
Chest 123: 410S-411S. [Full Text] [PDF]  

Airway Hyperresponsiveness

Paul M. O’Byrne and Mark D. Inman
Chest 123: 411S-416S. [Abstract] [Full Text] [PDF]  

Intercellular Adhesion Molecule-1 Plays a Pivotal Role in Endotoxin-Induced Airway Disease

David M. Brass, Jordan D. Savov, and David A. Schwartz
Chest 123: 416S. [Full Text] [PDF]  

Provocation With Adenosine 5'-Monophosphate Increases Sputum Eosinophils

Maarten van den Berge, H.A.M. Kerstjens, D.M. de Reus, H.F. Kauffman, G.H. Koëter, and D.S. Postma
Chest 123: 417S. [Full Text] [PDF]  

Airway Remodeling in Asthma

Antonio M. Vignola, Franco Mirabella, Giorgio Costanzo, Rossana Di Giorgi, Mark Gjomarkaj, Vincenzo Bellia, and Giovanni Bonsignore
Chest 123: 417S-422S. [Abstract] [Full Text] [PDF]  

Interleukin-13 Stimulates the Proliferation of Lung Myofibroblasts via a Signal Transducer and Activator of Transcription-6-Dependent Mechanism: A Possible Mechanism for the Development of Airway Fibrosis in Asthma

Jennifer L. Ingram, Annette Rice, Kristen Geisenhoffer, David K. Madtes, and James C. Bonner
Chest 123: 422S-424S. [Full Text] [PDF]  

Interleukin-4 Promotes Airway Remodeling in Asthma: Regulation of Procollagen I (₁) Gene by Interleukin-4

Céline Bergeron, Nathalie Pagé, Benoit Barbeau, and Jamila Chakir
Chest 123: 424S. [Full Text] [PDF]  

Mycoplasma pneumoniae Antigens Stimulate Interleukin-8

Kathryn Chmura, Ryan D. Lutz, Hirofumi Chiba, Mari S. Numata, Hee-Jung Choi, Giamila Fantuzzi, Dennis R. Voelker, and Edward D. Chan
Chest 123: 425S. [Full Text] [PDF]  

Lipopolysaccharide Down-regulates Leukotriene C₄ Synthase Gene Expression in a Cell-Specific Manner in the Monocyte-Like Cell Line, THP-1

Kenneth J. Serio, Scott C. Johns, Linda Luo, Craig R. Hodulik, and Timothy D. Bigby
Chest 123: 426S. [Full Text] [PDF]  

Pulmonary Surfactant Proteins A and D Recognize Lipid Ligands on Mycoplasma pneumoniae and Markedly Augment the Innate Immune Response to the Organism

Hirofumi Chiba, Surapon Pattanajitvilai, Hiroaki Mitsuzawa, Yoshio Kuroki, Amanda Evans, and Dennis R. Voelker
Chest 123: 426S. [Full Text] [PDF]  

Effects of Inhaled Fluticasone on Bronchial Hyperresponsiveness and Airway Inflammation in Mycoplasma pneumoniae-Infected Mice

Hong Wei Chu, Jennifer A. Campbell, Ronald J. Harbeck, and Richard J. Martin
Chest 123: 427S. [Full Text] [PDF]  

Synergetic Effect of Interleukin-4 and Transforming Growth Factor-ß1 on Type I Collagen Gel Contraction and Degradation by HFL-1 Cells: Implication in Tissue Remodeling

Xiangde Liu, Heather Conner, Tetsu Kobayashi, Shinji Abe, Qiuhong Fang, Fu-Qiang Wen, and Stephen I. Rennard
Chest 123: 427S-428S. [Full Text] [PDF]  

Quantitative Assessment of Subepithelial Collagen Deposition in the Airways of Mice Following Ovalbumin Sensitization and Intratracheal Challenge

Alistair K. Reinhardt, Stephen E. Bottoms, Goeffrey J. Laurent, and Robin J. McAnulty
Chest 123: 428S. [Full Text] [PDF]  

Increased Expression of Platelet-Derived Growth Factor Receptor-ß in Airway Fibroblasts of Severe Asthmatics

Christina C. Lewis, Hong Wei Chu, Jay Y. Westcott, E. Rand Sutherland, Allen D. Stevens, Terri L. Metze, and Monica Kraft
Chest 123: 428S-429S. [Full Text] [PDF]  

Modulation of Fibroblast Growth Factor Expression and Signal Transduction in Type II Cells

Cheng-Ming Li, Donna Newman, Mark Cesta, Leslie Tompkins, Jody Khosla, and Philip L. Sannes
Chest 123: 429S. [Full Text] [PDF]  

Airway Response to Low-Dose Allergen Exposure in Allergic Nonasthmatic and Asthmatic Subjects: Eosinophils, Fibronectin, and Vascular Endothelial Growth Factor

Marie-Eve Boulay and Louis-Philippe Boulet
Chest 123: 430S. [Full Text] [PDF]  

Risk-Benefit Value of Inhaled Corticosteroids: A Pharmacokinetic/Pharmacodynamic Perspective

Shashank Rohatagi, Hartmut Derendorf, and Karl Zech
Chest 123: 430S-431S. [Full Text] [PDF]  

Immunomodulatory Effect of Interleukin-16 on Allergic Airway Inflammation

Frederic F. Little, Joris de Bie, Anton van Oosterhout, Hardy Kornfeld, David M. Center, and William W. Cruikshank
Chest 123: 431S-432S. [Full Text] [PDF]  

Learning Occurs With Repetitions of Inspiratory Loading

Stasia Jastrzembski-Wieber, Marc Lavietes, Art Ritter, Tom C. Banwell, John Ricci, and Neil S. Cherniack
Chest 123: 432S-433S. [Full Text] [PDF]  

Identification of Birch Pollen Respirable Particles

Philip E. Taylor, Richard Flagan, Ann G. Miguel, Rudolf Valenta, and M. Michael Glovsky
Chest 123: 433S. [Full Text] [PDF]  

Regulation of Phospholipase A₂ by Interleulin-1 in Human Airway Smooth Muscle

Rudolfo M. Pascual, Bharat K. Awsare, Stephen A. Farber, Reynold A. Panettieri, Jr, Stephen P. Peters, and Raymond B. Penn
Chest 123: 433S-434S. [Full Text] [PDF]  

The Effect of House Dust Mite Aeroallergen and Air Pollutant Exposures During Infancy

Lisa A. Miller, Dallas M. Hyde, Laurel J. Gershwin, Edward S. Schelegle, Michelle V. Fanucchi, Michael J. Evans, Joan E. Gerriets, Lei F. Putney, Mary Y. Stovall, Nancy K. Tyler, Jodie L. Usachenko, and Charles G. Plopper
Chest 123: 434S. [Full Text] [PDF]  

Pediatric Asthma: An Approach to Pharmacogenetics Analysis

Stanley J. Szefler
Chest 123: 434S-438S. [Full Text] [PDF]  

Polymorphisms of the GM-CSF Genes and the Development of Atopic Diseases in At-Risk Children

Jian-Qing He, Jian Ruan, Moira Chan-Yeung, Allan B. Becker, Helen Dimich-Ward, Peter D. Paré, and Andrew J. Sandford
Chest 123: 438S. [Full Text] [PDF]  

Interleukin-13 and Interferon Modulators of Dendritic Cell Migration in the Lungs

Janice Hwang, David Yen, Thomas Tschernig, Donna Rennick, and Gabriele Grunig
Chest 123: 439S. [Full Text] [PDF]  

New and Exploratory Therapies for Asthma

Homer A. Boushey
Chest 123: 439S-445S. [Full Text] [PDF]  

Zinc Status Modulates Bronchopulmonary Eosinophil Infiltration in a Murine Model of Allergic Inflammation

Martin Richter, Richard Bonneau, Marie-Andrée Girard, Claudia Beaulieu, and Pierre Larivée
Chest 123: 446S. [Full Text] [PDF]  

Inhibition of Airway Inflammation and Hyperreactivity by a Catalytic Antioxidant

Ling Yi Chang and James D. Crapo
Chest 123: 446S. [Full Text] [PDF]  

Asthma and the Human Genome Project: Summary of the 45th Annual Thomas L. Petty Aspen Lung Conference

Jeffrey M. Drazen
Chest 123: 447S-449S. [Full Text] [PDF]  

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