SUPPLEMENT

Introduction: Mechanisms of COPD

Thomas L. Petty and Stephen I. Rennard
Chest 117: 219S. [Full Text] [PDF]  

Expiratory Flow Limitation : Roger S. Mitchell Lecture

Joseph Milic-Emili
Chest 117: 219S-223S. [Full Text] [PDF]  

Animal Models for COPD

Steven D. Shapiro
Chest 117: 223S-227S. [Full Text] [PDF]  

A Role for Collagenase (Matrix Metalloproteinase-1) in Pulmonary Emphysema

S. Dalal, K. Imai, B. Mercer, Y. Okada, K. Chada, and Jeanine M. D’Armiento
Chest 117: 227S-228S. [Full Text] [PDF]  

Experimental Evidence From an Animal Model of Adenocarcinoma That Chronic Inflammation Enhances Lung Cancer Risk

A.M. Malkinson, A. Bauer, A. Meyer, L. Dwyer-Nield, K. Koski, R. Keith, M. Geraci, and Y.-E. Miller
Chest 117: 228S. [Full Text] [PDF]  

Activation of an Embryonic Gene Product in Pulmonary Emphysema : Identification of the Secreted Frizzled-Related Protein

K. Imai and J. D’Armiento
Chest 117: 229S. [Full Text] [PDF]  

Lung Elastin and Matrix

Barry C. Starcher
Chest 117: 229S-234S. [Full Text] [PDF]  

Effect of Initial Collagen Concentration on Fibroblast Mediated Contraction of Collagen Gels

Yun Kui Zhu, T. Umino, X.D. Liu, H.J. Wang, Debra J. Romberger, John R. Spurzem, and Stephen I. Rennard
Chest 117: 234S-235S. [Full Text] [PDF]  

Effects of All-Trans-Retinoic Acid in Promoting Alveolar Repair

Paula N. Belloni, Laura Garvin, Cheng-Ping Mao, Irene Bailey-Healy, and David Leaffer
Chest 117: 235S-241S. [Full Text] [PDF]  

Cigarette Smoke Extract Decreases the Expression of Vascular Endothelial Growth Factor by Cultured Cells and Triggers Apoptosis of Pulmonary Endothelial Cells

R. M. Tuder, K. Wood, L. Taraseviciene, S. C. Flores, and N. F. Voekel
Chest 117: 241S-242S. [Full Text] [PDF]  

Can Retinoic Acid Ameliorate the Physiologic and Morphologic Effects of Elastase Instillation in the Rat?

Jeffrey Tepper, Juergen Pfeiffer, Melinda Aldrich, Daniel Tumas, Jeffrey Kern, Eric Hoffman, Geoffrey McLennan, and Dallas Hyde
Chest 117: 242S-244S. [Full Text] [PDF]  

Clinical Relevance Summary : Collagen vs Elastin in Pathogenesis of Emphysema; Cellular Origin of Elastases; Bronchiolitis vs Emphysema as a Cause of Airflow Obstruction

Gordon L. Snider
Chest 117: 244S-246S. [Full Text] [PDF]  

Pulmonary Mechanics of Papain Emphysema in Dogs

Robert E. Hyatt, G. Farkas, and M. Schroeder
Chest 117: 246S. [Full Text] [PDF]  

A Mouse Model of Cigarette Smoke-Induced Emphysema

Kristen J. Nikula, Thomas H. March, J. Seagrave, G. Finch, E. Barr, M. Ménache, F. Hahn, and C. Hobbs
Chest 117: 246S-247S. [Full Text] [PDF]  

A Study on the Effect of Cadmium on Human Lung Fibroblasts

Xiang-der Liu, T. Umino, Yun Kui Zhu, Hangjun Wang, John R. Spurzem, Debra J. Romberger, and Stephen I. Rennard
Chest 117: 247S. [Full Text] [PDF]  

A Cluster Analysis of CT Scans Predicts Patients Who Respond to Lung Volume Reduction Surgery

Harvey O. Coxson, Kenneth P. Whittall, Robert M. Rogers, Frank C. Sciurba, Robert J. Keenan, and James C. Hogg
Chest 117: 247S-248S. [Full Text] [PDF]  

Spontaneous Emphysema in Surfactant Protein D Gene-Targeted Mice

Susan Wert, Tracy Jones, Thomas Korfhagen, James Fisher, and Jeffrey Whitsett
Chest 117: 248S. [Full Text] [PDF]  

Glutathione Can Protect A549 From Smoke-Induced Inhibition of Collagen Gel Contraction

Hangjun Wang, T. Umino, Xiang-der Liu, Yun Kui Zhu, M. Patricia Leuschen, John R. Spurzem, Debra J. Romberger, and Stephen I. Rennard
Chest 117: 248S-249S. [Full Text] [PDF]  

Cognitive Improvement Following Rehabilitation in Patients With COPD

Elizabeth Kozora and Barry J. Make
Chest 117: 249S. [Full Text] [PDF]  

Polymorphisms of Surfactant Protein Gene A, B, D, and of SP-B-linked Microsatellite Markers in COPD of a Mexican Population

Xiaoxuan Guo, Hung-Mo Lin, Zhenwu Lin, Martha Montaño, Raul Sansores, Guirong Wang, Susan DiAngelo, Annie Pardo, Moises Selman, and Joanna Floros
Chest 117: 249S-250S. [Full Text] [PDF]  

Lung Neutrophil Burden Correlates With Increased Pro-Inflammatory Cytokines and Decreased Lung Function in Individuals With ₁-Antitrypsin Deficiency

F. Rouhani, G. Paone, N. K. Smith, P. Krein, P. Barnes, and Mark L. Brantly
Chest 117: 250S-251S. [Full Text] [PDF]  

Comparison of the Structural and Inflammatory Features of COPD and Asthma Giles F. Filley Lecture

Peter K. Jeffery
Chest 117: 251S-260S. [Abstract] [Full Text] [PDF]  

Expression of 15-Lipoxygenase and Evidence for Apoptosis in the Lungs From Patients With COPD

Yasunori Kasahara, Rubin M. Tuder, Carlyne D. Cool, and Norbert F. Voelkel
Chest 117: 260S. [Full Text] [PDF]  

Morphometry Explains Variation in Airway Responsiveness in Transgenic Mice Overexpressing Interleukin-6 and Interleukin-11 in the Lung

Charles Kuhn, Robert J. Homer, Zhou Zhu, Nicholas Ward, and Jack A. Elias
Chest 117: 260S-262S. [Full Text] [PDF]  

Ongoing Airway Inflammation in Patients With COPD Who Do Not Currently Smoke

Steven R. Rutgers, Dirkje S. Postma, Nick H. ten Hacken, Henk F. Kauffman, Thomas W. van der Mark, Gerard H. Koëter, and Wim Timens
Chest 117: 262S. [Full Text] [PDF]  

Mechanisms of Airway Hypersecretion and Novel Therapy

Jay A. Nadel
Chest 117: 262S-266S. [Full Text] [PDF]  

Myristoylated Alanine-Rich C-Kinase Substrate Protein : A Major Intracellular Regulatory Molecule Controlling Secretion of Mucin by Human Airway Goblet Cells

Kenneth B. Adler, Y. Li, and L. D. Martin
Chest 117: 266S-267S. [Full Text] [PDF]  

Response of Human Airway Epithelium In Vitro to Inflammatory Mediators : Dependence on the State of Cellular Differentiation

Linda D. Martin, Derek Norford, Judith Voynow, and Kenneth B. Adler
Chest 117: 267S. [Full Text] [PDF]  

Skeletal Muscle Function in COPD

Richard Casaburi
Chest 117: 267S-271S. [Abstract] [Full Text] [PDF]  

Chronic Alveolar Hypoventilation Helps To Maintain the Inspiratory Muscle Effort of COPD Patients Within Sustainable Limits

Paul Bégin and Alejandro Grassino
Chest 117: 271S-273S. [Full Text] [PDF]  

Familial Aggregation of Severe, Early-Onset COPD : Candidate Gene Approaches

Edwin K. Silverman, Frank E. Speizer, Scott T. Weiss, Harold A. Chapman, Jr., Austin Schuette, Edward J. Campbell, John J. Reilly, Jr., Leo C. Ginns, and Jeffrey M. Drazen
Chest 117: 273S-274S. [Full Text] [PDF]  

Nutrition and Metabolism in COPD

Emiel F.M. Wouters
Chest 117: 274S-280S. [Full Text] [PDF]  

Comparison of Bone Mineral Density in Elderly Female Patients With COPD and Bronchial Asthma

Hideki Katsura and Kozui Kida
Chest 117: 280S. [Full Text] [PDF]  

Inhibition of Vascular Endothelial Growth Factor Receptors Causes Emphysema in Rats

Rubin M. Tuder, Yasanori Kasahara, and Norbert F. Voelkel
Chest 117: 281S. [Full Text] [PDF]  

Exhaled Nitric Oxide and Induced Sputum Analysis as Markers of Airway Inflammation in Subjects With COPD

Philip E. Silkoff, D. Martin, Juno Pak, and Richard J. Martin
Chest 117: 281S. [Full Text] [PDF]  

Proteases and Chemotactic Factors in BAL Fluid From Subjects With Subclinical Emphysema

Masaharu Nishimura, Tomoko Betsuyaku, Mishie Tanino, Kimihiro Takeyabu, Kenji Miyamoto, and Yoshikazu Kawakami
Chest 117: 282S. [Full Text] [PDF]  

Latent Adenoviral Infection in the Pathogenesis of Emphysema : The Parker B. Francis Lectureship

James C. Hogg
Chest 117: 282S-285S. [Full Text] [PDF]  

HIV Infection Increases Susceptibility to Smoking-Induced Emphysema

Philip T. Diaz, Eric R. King, Mark D. Wewers, James E. Gadek, David Neal, Janice Drake, and Thomas L. Clanton
Chest 117: 285S. [Full Text] [PDF]  

Airway Inflammation and Hyperresponsiveness to Adenosine 5'-Monophosphate in COPD

Steven R. Rutgers, Huib AM Kerstjens, Wim Timens, Nikolaos Tzanakis, Henk F. Kauffman, and Dirkje S. Postma
Chest 117: 285S. [Full Text] [PDF]  

Bacterial Infection and the Pathogenesis of COPD

Sanjay Sethi
Chest 117: 286S-291S. [Abstract] [Full Text] [PDF]  

Bronchial Inflammation : Its Relationship to Colonizing Microbial Load and ₁-Antitrypsin Deficiency

Robert A. Stockley, Adam T. Hill, Susan L. Hill, and Edward J. Campbell
Chest 117: 291S-293S. [Abstract] [Full Text] [PDF]  

The Role of Haemophilus parainfluenzae in COPD

Susan L. Hill, J. L. Mitchell, Robert A. Stockley, and Robert Wilson
Chest 117: 293S. [Full Text] [PDF]  

Mechanisms of COPD : Clinical Relevance of Research Presentations at the Thomas Petty Aspen Lung Conference 1999

Robert M. Rogers
Chest 117: 294S-295S. [Full Text] [PDF]  

Protease Injury in the Development of COPD : Thomas A. Neff Lecture

Harold A. Chapman, Jr. and Guo-Ping Shi
Chest 117: 295S-299S. [Full Text] [PDF]  

The Dutch Hypothesis

N. G. M. Orie
Chest 117: 299S. [Full Text] [PDF]  

The Combination of Elastase and Sulfur Dioxide Exposure Causes COPD-Like Lesions in the Rat

Urmila P. Kodavanti, Mette C. Jackson, Allen D. Ledbetter, Barry C. Starcher, Paul A. Evansky, Adrian Harewood, Darrell W. Winsett, and Daniel L. Costa
Chest 117: 299S-302S. [Full Text] [PDF]  

Evidence for Neutrophil Involvement in the Development of Subclinical Emphysema

Tomoko Betsuyaku, Masaharu Nishimura, Kimihiro Takeyabu, Mishie Tanino, P. Venge, S. Xu, and Yoshikazu Kawakami
Chest 117: 302S-303S. [Full Text] [PDF]  

Quantum Proteolysis by Neutrophils : Implications for Pulmonary Emphysema in ₁-Antitrypsin Deficiency

Edward J. Campbell, M. A. Campbell, S. S. Boukedes, and Caroline A. Owen
Chest 117: 303S. [Full Text] [PDF]  

Oxidants/Antioxidants and COPD

William MacNee
Chest 117: 303S-317S. [Abstract] [Full Text] [PDF]  

Neutrophil Elastase Induces MUC5AC Messenger RNA Expression by an Oxidant-Dependent Mechanism

Bernard Fischer and Judith Voynow
Chest 117: 317S-320S. [Abstract] [Full Text] [PDF]  

Apoptosis of Alveolar Macrophages by Cigarette Smoke

Kazutetsu Aoshiba, Shuju Yasui, and Atsushi Nagai
Chest 117: 320S. [Full Text] [PDF]  

Mechanisms of COPD : Conference Summary

Robert M. Senior
Chest 117: 320S-323S. [Full Text] [PDF]  

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