Chest ACCP Career Connection
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Meyers, D. A.
Right arrow Articles by Lange, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Meyers, D. A.
Right arrow Articles by Lange, L.
(Chest. 2004;126:105S-110S.)
© 2004 American College of Chest Physicians

Genetics of Asthma and COPD*

Similar Results for Different Phenotypes

Deborah A. Meyers, PhD; Michael J. Larj, PhD, FCCP and Leslie Lange, PhD

* From the Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC.

Correspondence to: Deborah A. Meyers, PhD, Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157

Asthma and COPD are common respiratory diseases that are caused by the interaction of genetic susceptibility with environmental factors. Environmental influences are important in both diseases, and although there are differences in genetic susceptibilities, there are also similarities. Three examples of interest for both asthma and COPD patients are discussed. The first is the results of family studies, which have shown evidence for susceptibility loci for both asthma-related and COPD-related phenotypes in the same chromosomal region. Second, evidence for a gene-environment interaction with passive smoking for asthma patients compared with individual smoking for COPD patients will be covered. The third is an example of one candidate gene (interleukin-13), in which similar results have been observed for both asthma and COPD.

Key Words: asthma • COPD • FEV1 • FVC




This article has been cited by other articles:


Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. J. Holtzman, J. T. Battaile, and A. C. Patel
Immunogenetic Programs for Viral Induction of Mucous Cell Metaplasia
Am. J. Respir. Cell Mol. Biol., July 1, 2006; 35(1): 29 - 39.
[Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
M. J. Holtzman, J. W. Tyner, E. Y. Kim, M. S. Lo, A. C. Patel, L. P. Shornick, E. Agapov, and Y. Zhang
Acute and Chronic Airway Responses to Viral Infection: Implications for Asthma and Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, August 1, 2005; 2(2): 132 - 140.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2004 by the American College of Chest Physicians.