Chest Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (4)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kellerman, D. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kellerman, D. J.
(Chest. 2002;121:201S-205S.)
© 2002 American College of Chest Physicians

P2Y2 Receptor Agonists*

A New Class of Medication Targeted at Improved Mucociliary Clearance

Donald J. Kellerman, PharmD

* From Inspire Pharmaceuticals, Durham, NC.

Correspondence to: Donald J. Kellerman, PharmD, Sr. Vice President, Development, Inspire Pharmaceuticals, 4222 Emperor Blvd, Suite 470, Durham, NC 27703; e-mail: dk{at}inspirepharm.com

Chronic bronchitis is in part characterized by mucus hypersecretion and the inability to clear airways of mucus. Despite years of research in this area, to date there are no pharmacologic therapies available to enhance or promote mucociliary clearance. P2Y2 receptor agonists are a new class of mucoactive compounds that are currently under development for this purpose. This article will review the pharmacology of P2Y2 receptor agonists, review the clinical studies performed to date, and highlight the challenges inherent in the development of therapies with these pharmacologic properties.

Key Words: COPD • chronic bronchitis • cystic fibrosis • INS365 • mucociliary clearance • purinergic receptors • P2Y receptors • uridine triphosphate




This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
T. Ohashi, Y. Ito, T. Matsuno, S. Sato, K. Shimokata, and H. Kume
Paradoxical Effects of Hydrogen Peroxide on Human Airway Anion Secretion
J. Pharmacol. Exp. Ther., July 1, 2006; 318(1): 296 - 303.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
R. Buhl and S. G. Farmer
Future Directions in the Pharmacologic Therapy of Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, April 1, 2005; 2(1): 83 - 93.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
R. Buhl and S. G. Farmer
Current and Future Pharmacologic Therapy of Exacerbations in Chronic Obstructive Pulmonary Disease and Asthma
Proceedings of the ATS, April 1, 2004; 1(2): 136 - 142.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
Y. Ito, M. Son, S. Sato, T. Ishikawa, M. Kondo, S. Nakayama, K. Shimokata, and H. Kume
ATP Release Triggered by Activation of the Ca2+-Activated K+ Channel in Human Airway Calu-3 Cells
Am. J. Respir. Cell Mol. Biol., March 1, 2004; 30(3): 388 - 395.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. Son, Y. Ito, S. Sato, T. Ishikawa, M. Kondo, S. Nakayama, K. Shimokata, and H. Kume
Apical and Basolateral ATP-Induced Anion Secretion in Polarized Human Airway Epithelia
Am. J. Respir. Cell Mol. Biol., March 1, 2004; 30(3): 411 - 419.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
B. Robaye, E. Ghanem, F. Wilkin, D. Fokan, W. Van Driessche, S. Schurmans, J.-M. Boeynaems, and R. Beauwens
Loss of Nucleotide Regulation of Epithelial Chloride Transport in the Jejunum of P2Y4-Null Mice
Mol. Pharmacol., April 1, 2003; 63(4): 777 - 783.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2002 by the American College of Chest Physicians.