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(Chest. 2002;121:131S-135S.)
© 2002 American College of Chest Physicians

Muscle Metabolism and Exercise Tolerance in COPD*

Michael I. Polkey, PhD

* From the Royal Brompton Hospital, London, UK.

Correspondence to: Michael I. Polkey, PhD, Royal Brompton Hospital, Fulham Rd, London SW3 6NP, United Kingdom; e-mail: m.polkey{at}rbh.nthames.nhs.uk

This article explores the hypothesis that dyspnea in patients with COPD arises from an imbalance between the load placed on the respiratory muscle pump and its capacity. Evidence to support this concept is presented, and possible therapeutic approaches are discussed.

Key Words: COPD • dyspnea • exercise tolerance • metabolism • skeletal muscle






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