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(Chest. 2002;121:7S-13S.)
© 2002 American College of Chest Physicians

Asthma Genetics*

William Osmond Charles Cookson, MA, DPhil, MD

* From the Department of Human Genetics, University of Oxford, Oxford, UK.

Correspondence to: William Osmond Charles Cookson, MA, DPhil, MD, Wellcome Trust Centre for Human Genetics, Roosevelt Dr, Headington, Oxford OX3 7BN, UK; e-mail: wocc{at}well.ox.ac.uk

Asthma is the most common chronic childhood disease in developed nations and is a complex disease that has high social and economic costs. Asthma and its associated intermediate phenotypes are under a substantial degree of genetic control. Identifying the genes underlying asthma offers a means of better understanding its pathogenesis, with the promise of improving preventive strategies, diagnostic tools, and therapies. A number of chromosomal regions containing genes influencing asthma and atopy have been identified consistently by different groups, and a role for several candidate genes has been established.




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