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(Chest. 2000;117:267S-271S.)
© 2000 American College of Chest Physicians

Skeletal Muscle Function in COPD*

Richard Casaburi, PhD, MD, FCCP

* From the Division of Respiratory and Critical Care Physiology and Medicine, Harbor-UCLA Medical Center, Torrance, CA.

Correspondence to: Richard Casaburi, PhD, MD, FCCP, Box 405, Harbor-UCLA Medical Center, 1000 W. Carson St, Torrance, CA 90509; e-mail: casaburi{at}ucla.edu

Few effective therapies exist for patients with COPD. Rehabilitative therapy aimed at curing dysfunction of the peripheral muscles may be an appropriate addition to this short list. This review does the following: (1) presents evidence that skeletal muscle dysfunction is present in COPD patients; (2) considers the mechanisms of this dysfunction; (3) describes the role of exercise training in correcting this disorder; and (4) speculates that anabolic hormone supplementation may find a place in COPD therapy. Further research will be necessary to refine these concepts.

Key Words: anabolic • COPD • exercise • growth hormone • muscle • strength • testosterone






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