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(Chest. 1998;113:46S-52S.)
© 1998 American College of Chest Physicians

Considerations in Optimizing Radiation Therapy for Non-small Cell Lung Cancer

Joel S. Greenberger MD1; Sanjeev Bahri MD1; James Jett MD, FCCP1; Chandra Belani MD1; Andre Kalend PhD1; and Michael Epperly PhD1

1 From the Department of Radiation Oncology, University of Pittsburgh Medical Center and University of Pittsburgh Cancer Institute

Irradiation therapy for lung cancer is mostly restricted to conventional methods. To improve therapeutic ratio, we have combined a treatment planning and a gene therapy approach. Three-dimensional conformal radiotherapy is described as carried out by methods of gene therapy for radiation protection using the manganese-superoxide-dismutase transgene delivered by inhalation gene transfer. These methods may improve therapeutic outcomes in lung cancer.






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Copyright © 1998 by the American College of Chest Physicians.