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(Chest. 1997;112:195S-200S.)
© 1997 American College of Chest Physicians

Multimodality Therapy for Esophageal Cancer

Arlene A. Forastiere MD1; Richard F. Heitmiller MD1; and Lawrence Kleinberg MD1

1 From the Departments of Oncology and Surgery, Johns Hopkins University School of Medicine, Baltimore

Over the past decade and a half, several strategies have been developed to improve the survival of patients with esophageal cancer. Two strategies employ either neoadjuvant chemotherapy or chemoradiotherapy followed by surgery to improve local-regional control and decrease the incidence of distant metastases. A third strategy uses nonsurgical therapy as definitive treatment for patients without metastatic disease. Single-institution pilot trials and randomized comparative trials have been conducted evaluating each approach. The rationale for these trials, results, and current recommendations are presented.







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Copyright © 1997 by the American College of Chest Physicians.